Changes in hepatic microsomal enzyme function in workers exposed to mixtures of chemicals

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Abstract
Antipyrine clearance was measured during occupational exposure and after an exposure-free interval of 3 wk in 26 spray painters, 44 workers in a herbicide-producing (phenoxyacids) plant and 10 pesticide-exposed greenhouse gardeners. A control group of 39 workers were investigated simultaneously. A noninvasive simplified antipyrine clearance was used. Antipyrine clearance was 15% greater in workers exposed to phenoxyacids and chlorophenols and 21% greater in pesticide-exposed persons; it was 15% less in workers exposed to spray paints compared to 3 wk after discontinuation of exposure. Clearance was unchanged in the control group. The combined action of different spray paints, grinding dust and cleaners may have inhibited, and phenoxyacids, chlorophenols and pesticides may have induced, microsomal enzyme function. The workers had been exposed to the chemicals for years, but the change in antipyrine clearance apparently was reversible.

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