Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. IV. The Antioxidative Action of Copper Chlorins

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Abstract
The relationship between the antioxidative action of sodium copper chlorophyllin (Cu-Chl-Na) and its chemical structure was examined. By the aerobic incubation of Cu-Chl-Na in aqueous solution, the spectral absorbances of the solution at Soret (406 nm) and red (632 nm) maxima decreased while the ratio of the absorbances (Soret/red) increased. Since the Cu-Chl-Na incubated aerobically lost its original antioxidative activity, the thiobarbituric acid values in the rat liver homogenates treated with Fe2+ and ascorbic acid increased, and a decrease in the reduction of 1,1-diphenyl-2-picrylhydrazyl was observed. Cu-Chl-Na reacted directly with 1,1-diphenyl-2-picrylhydrazyl to decrease the spectral absorbances at both Soret and red maxima and to increase the ratio of the absorbances (Soret/red). Since the spectral absorption in the red-band region is attributable to the absorption of copper chlorin structure, the results suggest that copper chlorins are responsible for the antioxidative activity of Cu-Chl-Na.

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