Use of Amino Acid Containing Solution in CAPD Patients

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Abstract
A number of CAPD patients may develop malnutrition due to multiple causes. Average daily amino acid loss during CAPD was 2 gm per day. Serum concentrations of almost all essential and non essential amino acids were significantly lower than controls. Amino acid containing solution is an effective osmotic agent and at the same time is suitable for nutritional supplementation. Use of this solution up to 4 weeks did not lead to any abnormal accumulation of amino acids and patient appeared to tolerate it well. A number of CAPD patients may develop malnutrition which appears to be brought about by a combination of decreased appetite, and increased nutrient loss in the dialysate. In a group of 13 patients whose daily protein and caloric intakes at the beginning of CAPD were 1.5 9 per kg, and 35 Kcal/kg respectively, intakes decreased spontaneously after one year on CAPD even though they were being advised during their clinic visits to maintain initial protein and caloric intakes (1). Reduced intakes appear to result from decreased appetite and a feeling of fullness, although these factors are difficult to evaluate quantitatively. To gain information as to the etiology of appetite suppression during CAPD, we performed CAPD in nonuremic rabbits.