EFFECTS OF THEOPHYLLINE ON URINARY-EXCRETION OF CYCLIC-AMP, CALCIUM, AND PHOSPHORUS IN NORMAL SUBJECTS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 10  (6) , 359-361
Abstract
The effects of acute theophylline administration on urinary excretion of cAMP, Ca and P in normal subjects were examined. At therapeutic doses (5 mg i.v./kg body weight) theophylline exerted a distinct biologic effect on renal tubular activity in 5 normal subjects: an increase in nephrogenous cAMP accompanied by a rise in phosphate and Ca urinary excretion. Beyond the clinical implications, the data suggest that theophylline, in contrast to parathyroid hormone, may be acting via cAMP to exert both its phosphaturic and calciuric effect on renal tubules.

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