EFFECTS OF CHOLECYSTOKININ PREPARATION ON THE MOVEMENTS OF THE STOMACH AND SMALL INTESTINE

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Abstract
In dogs anesthetized with pentobarbital sodium, the intravenous administration of 0.5 to 1 Ivy dog unit/kg CCKV (Cecekin Vitrum) produced the excitation of the movements of the gall bladder, stomach and small intestine. After the administration of atropine or hexamethonium the excitatory effect was not abolished. The motility of the isolated duodenal loop of a rabbit was increased by the administration of CCKV. The excitatory effect of the agent on the excised muscle strip of the dog jejunum was less than that in the rabbit intestine. About 1.5 min. after perfusing the lumen of the isolated jejunum with N/10 HCl solution, the gall bladder began to contract and several minutes later the contraction reached its maximum, while there occurred no response in the jejunal movements. Pure cholecystokinin exerts no effect on the motility of the small intestine, and a potent preparation of cholecystokinin (Cecekin Vitrum) is not a purified cholecystokinin, but contains some unknown substance to excite movements of the small intestine and stomach.

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