A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors
- 1 June 2006
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (11) , 2900-2904
- https://doi.org/10.1016/j.bmcl.2006.03.003
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cellsBioorganic & Medicinal Chemistry Letters, 2005
- Integrase inhibitors to treat HIV/AidsNature Reviews Drug Discovery, 2005
- A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integraseProceedings of the National Academy of Sciences, 2004
- Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus MacaquesScience, 2004
- Structure and Function of HIV-1 IntegraseCurrent Topics in Medicinal Chemistry, 2004
- HIV-1 integrase: a target for new AIDS chemotherapeutics.Current Topics in Medicinal Chemistry, 2004
- Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected CellsJournal of Medicinal Chemistry, 2003
- 4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in CellsJournal of Medicinal Chemistry, 2000
- Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug designProceedings of the National Academy of Sciences, 1999
- L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.Proceedings of the National Academy of Sciences, 1994