A possible role for 5-hydroxytryptamine as a mediator for calcitonin actions on the gastrointestinal tract and pancreas in rats

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Abstract
Administration of pig calcitonin (10 M.R.C. [U.K. Medical Research Council] units/kg body wt) produced an immediate decrease in 5-hydroxytryptamine [5-HT] content in the antrum-duodenum region and ileum. In contrast, the hormone treatment rapidly increased the concentration of 5-HT in the blood and pancreas. Serum immunoreactive gastrin did not change over a period of 3 h after calcitonin administration. The release of 5-HT probably mediates calcitonin actions on the gastrointestinal tract and pancreas.