STUDIES ON THE EFFECTS OF ANTI-INFLAMMATORY ACTION OF BENZOYL-HYDROTROPIC ACID (KETOPROFEN) AND OTHER DRUGS, WITH SPECIAL REFERENCE TO PROSTAGLANDIN SYNTHESIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 237  (1) , 169-176
Abstract
Effects of ketoprofen, indomethacin, phenylbutazone and acetylsalicylic acid on edema and on in vivo and in vitro synthesis of PG[prostaglandin]E1, PGE2 and PGF2.alpha. in response to carrageenin were studied in rats. Ketoprofen was a potent drug in depressing edema and increased PGE1, PGE2 and PGF2.alpha. in response to carrageenin. Ketoprofen inhibited in vitro synthesis of PGE2 and PGF2.alpha. from arachidonic acid. The relative potency of ketoprofen in those parameters was comparable to or greater than that of indomethacin. Phenylbutazone and acetylsalicyclic acid were less potent in this respect. Ketoprofen may manifest its anti-inflammatory action, in part, by inhibiting PG synthesis.

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