Studies on the fungitoxicity of captan

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Abstract
SUMMARY: The solubility, olelyl alcohol‐water partition coefficient, fungistatic activity to Alternaria tenuis and Neurospora crassa, and spore uptake by N. crassa of captan and six analogues have been determined. The analogues were structurally similar, possessing a phthalimide moiety and ‐NSCCl3 group, but differed in their lipid solubility. This variation in lipid solubility was not reflected in either fungitoxicity or spore uptake except for the two compounds with the lowest partition coefficients, N‐(trichloromethylthio)‐3,6‐endoxohexahydrophthalimide and N‐(trichloromethylthio)‐4,5‐epoxyhexahydrophthalimide. The high levels of uptake of the compounds required to inhibit spore germination and the high values of their estimated thermodynamic activities suggest unspecific mechanisms of toxicity and possible detoxication of the fungicides before they reach vital cellular sites.