Interactions between central monoaminergic systems: dopamine-serotonin.

1 December 1979

journal article
research article
Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry

Vol. 42 (12) , 1159-1162
https://doi.org/10.1136/jnnp.42.12.1159

Abstract

Concentration of dopamine and serotonin metabolites (HVA [homovanillic acid] and 5-HIAA hydroxyindoleacetic acid) in the CSF was evaluated before and after pharmacological treatment in 19 patients with different neuropsychiatric diseases. In every case a reciprocal modification of the 2 metabolites occurred after treatment. The hypothesis of a functional balance between the monoaminergic systems in the CNS is supported.

This publication has 12 references indexed in Scilit:

Biochemical Studies with Trazodone
Published by S. Karger AG ,2015
[Choreic dyskinesia and GABA - pharmaco-clinical approach. Preliminary note].
1978
Quipazine: Its effects on rat brain 5-hydroxytryptamine metabolism, monoamine oxidase activity and behaviour
Neuropharmacology, 1976
Single and repeated administration of neuroleptic drugs to rats: Effects on striatal dopamine-sensitive adenylate cyclase and locomotor activity produced by tranylcypromine and L-tryptophan or L-dopa
Psychopharmacology, 1976
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.
1975
ET495 and brain catecholamine mechanisms: Evidence for stimulation of dopamine receptors
European Journal of Pharmacology, 1972
Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid
Biochemical Pharmacology, 1971
Fluorometric determination of homovanillic acid in biological material after isolation on Sephadex G-10
Analytical Biochemistry, 1971
Decrease in homovanillic acid as evidence for dopamine receptor stimulation by apomorphine in the neostriatum of the rat
Journal of Pharmacy and Pharmacology, 1969
Classification of mental disorders.
1959