Role of the limbic system in active and passive avoidance conditioning in the rat.

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Abstract
Brain-damaged and normal rats were trained to run from the start box to the end box in order to avoid shock (active avoidance response) and subsequently were trained not to run from the start box to the end box in order to avoid shock (passive avoidance response). Destruction of either the hippo-campo-septal system, rostal internal capsule, or medial hypothalamus interfered with acqusition of both avoidance habits. Lesions of the medial thalamus, amygdala, medial forebrain bundle, or ventral mid-brain interfered only with acquisition of active avoidance.