Platelet angiotensin II binding sites in normotensive and hypertensive women

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Abstract
Summary. Specific binding of angiotensin II (AII) to platelets was measured in 89 women, 25 nulliparous non-pregnant women and 64 primigravida in the third trimester of pregnancy. There was significantly lower binding in the 25 pregnant women who were normotensive (2.3 fmol/109 cells) when compared with the non-pregnant women (9.0 fmol/109 cells P9 cells) when compared with the 25 normotensive pregnant women (P9 cells), when compared with the 16 who had non-proteinuric PIH, (4.6 fmol/109 cells) although the difference was not statistically significant (P<0.04). The pressor response to AII is also diminished in pregnancy, yet less so if pregnancy induced hypertension develops. Platelets may provide a readily accessible tissue with which to study AII responsiveness in pregnancy.