SERUM HALF-LIFE OF INTRAVENOUSLY INJECTED INTESTINAL AND HEPATIC ALKALINE-PHOSPHATASE ISOENZYMES IN CAT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (10) , 1637-1639
Abstract
The serum half-life of feline intestinal alkaline phosphatase (ALP) in the cat was 2 min and that of feline hepatic ALP, 5.8 h. The feline hepatic ALP could not be identified in urine of cats, nor was the clearance rate affected by bilateral nephrectomy. The short serum half-life of hepatic ALP was not a result of renal excretion. Since canine hepatic ALP cleared from feline blood at the same rate as the feline hepatic ALP, possibly the discrepancy in hepatic ALP half-life between the species was related to the cats'' ability to clear the blood of this enzyme.

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