Interleukin-10 promoter polymorphisms in male and female fertility and fecundity
Open Access
- 19 October 2006
- journal article
- research article
- Published by Springer Nature in Genes & Immunity
- Vol. 7 (8) , 688-692
- https://doi.org/10.1038/sj.gene.6364347
Abstract
Interleukin-10 (IL10) is assumed beneficial for a successful pregnancy; it may increase fertility and fecundity. Allele frequencies of IL10 polymorphisms at position −2849, −1082 and −592 were analyzed in association with a past history of fertility and fecundity in men and women of at least 85 years old. Fertility was decreased in association with the −2849 A allele in females; 27% of the AA genotype carriers produced no offspring in marriage compared to 14% of the G allele carriers (odds ratio (OR): 2.2, 95% confidence interval (CI): 1.2–4.2, P=0.01). Effective fecundability was decreased in association with the –2849 A allele in females; 7% of female −2849 AA genotype carriers had a child within 371 days of marriage (therefore, conceived within 3 months of marriage) compared to 28% of female G allele carriers (OR: 0.2, 95% CI: 0.04–0.7, P=0.01). This suggests an association between the –2849 AA genotype and a decreased fertility and fecundity in females.Keywords
This publication has 26 references indexed in Scilit:
- Impaired innate immunity predicts frailty in old age. The Leiden 85-plus studyExperimental Gerontology, 2004
- Cox proportional hazards survival regression in haplotype-based association analysis using the Stochastic-EM algorithmEuropean Journal of Human Genetics, 2004
- Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programmingThe FASEB Journal, 2004
- RELATION BETWEEN IMMUNOSUPPRESSIVE PGE 2 AND IL-10 TO PRO-INFLAMMATORY IL-6 IN SEMINAL PLASMA OF INFERTILE AND FERTILE MENArchives of Andrology, 2003
- Differential regulation of interleukin-10 production by genetic and environmental factors – a twin studyGenes & Immunity, 2002
- Immunology and immunopathology of the male genital tract: Control and impairment of immune privilege in the testis and in semenHuman Reproduction Update, 2001
- Interleukin-10 and the Interleukin-10 ReceptorAnnual Review of Immunology, 2001
- Genetic influence on cytokine production in meningococcal diseaseThe Lancet, 1997
- Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?Immunology Today, 1993
- Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.The Journal of Experimental Medicine, 1991