Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro
- 1 February 1980
- journal article
- research article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 267 (1) , 91-95
- https://doi.org/10.1007/bf00416927
Abstract
Summary The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10-6M and 2x10-6 M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitive as the evidence of arsenic-induced chromosomal aberrations in vitro.Keywords
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