Attenuation by oralN-acetylcysteine of bleomycin-induced lung injury in rats
- 1 June 2001
- journal article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 17 (6) , 1228-1235
- https://doi.org/10.1183/09031936.01.00049701
Abstract
Antioxidant therapy may be useful in diseases with impaired oxidant-antioxidant balance such as pulmonary fibrosis. This study examines the effect ofN-acetylcysteine (NAC) on bleomycin-induced lung fibrosis in rats.NAC (3 mmol·kg−1; oral) was given daily from 1 week prior to a single intratracheal instillation of bleomycin (2.5 U·kg−1) or saline, until 14 days postinstillation.NAC partially decreased the augmented collagen deposition in bleomycin-exposed rats (hydroxyproline content was 4,354±386 and 3,416±326 µg·lung−1in vehicle-treated and NAC-treated rats, respectively; pN-acetylcysteine improves the pulmonary antioxidant protection and may be useful in reducing lung damage produced by bleomycin.Keywords
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