Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis
Open Access
- 1 August 2001
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (8) , 5212-5215
- https://doi.org/10.1128/iai.69.8.5212-5215.2001
Abstract
Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.Keywords
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