Properties and Functions of Scatter Factor/Hepatocyte Growth Factor and Its Receptor c-Met
- 1 March 1993
- journal article
- research article
- Published by American Thoracic Society in American Journal of Respiratory Cell and Molecular Biology
- Vol. 8 (3) , 229-237
- https://doi.org/10.1165/ajrcmb/8.3.229
Abstract
Scatter factor (SF), a cell motility factor with a multimodular structure, is identical to hepatocyte growth factor (HGF), a potent mitogen of various cell types. The receptor for SF/HGF has recently been identified as the c-Met proto-oncogene product, a transmembrane receptor tyrosine kinase. Depending on the target cells and culture conditions, SF/HGF has several distinct activities in vitro, i.e., it induces cell motility, proliferation, invasiveness, tubular morphogenesis, angiogenesis, or cytotoxicity. In vivo, SF/HGF might be involved in tissue regeneration, tumor progression, and embryological processes.Keywords
This publication has 49 references indexed in Scilit:
- Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unitCell, 1992
- Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cellsHepatology, 1992
- Hepatocyte growth factor has potent anti‐proliferative activity in various tumor cell linesFEBS Letters, 1991
- Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factorBiochemical and Biophysical Research Communications, 1991
- Sequestration of a hepatocyte growth factor in extracellular matrix in normal adult rat liverBiochemical and Biophysical Research Communications, 1991
- Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTEBiochemical and Biophysical Research Communications, 1991
- Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyteBiochemical and Biophysical Research Communications, 1990
- Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factorBiochemical and Biophysical Research Communications, 1989
- Purification and subunit structure of hepatocyte growth factor from rat plateletsFEBS Letters, 1987
- Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityNature, 1987