PLASMA-LEVELS OF IMMUNOREACTIVE PARATHYROID-HORMONE IN DOGS CHRONICALLY EXPOSED TO LOW-LEVELS OF CADMIUM CHLORIDE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 2  (4) , 1151-1159
Abstract
Chronic Cd intoxication interfered with Ca accumulation in bone and the mechanism may be a parathyroid-induced bone resorption. C-terminal parathyroid hormone levels were measured in the blood of 4 male standardized research beagles chronically exposed during 6 mo. to 25 ppm CdCl2 in their drinking water, while at the same time measurements of the parameters of Haversian bone remodeling activity were performed. No statistically significant difference in levels of this hormone in experimental dogs before or during exposure, or between samples obtained from experimental dogs at the end of their period of exposure and normal untreated control dogs from the same colony was demonstrated. In early stages of chronic Cd intoxication, before evidence of intestinal or renal malfunction that may secondarily involve the parathyroid glands, the alteration observed in Haversian bone remodeling rates is not mediated through abnormalities of function of the parathyroid glands.

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