The Clinical Importance of Coagulase-Positive, Penicillin-ResistantStaphylococcus aureus

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Abstract
PENICILLIN-resistant Staphylococcus aureus has been isolated with increasing frequency since the introduction of this agent in 1941. Rammelkamp and Maxon1 tested 29 strains of Staph. aureus in 1942. All were inhibited by low concentrations of penicillin on initial isolation, but resistant organisms appeared in 4 cases after the administration of the drug. During 1943, Spink and his associates2 reported 12 per cent of 68, and Rantz and Kirby3 26 per cent of 43 strains to be penicillin resistant. Kirby4 recovered similar organisms from 7 patients, none of whom had received penicillin.Gallardo,5 in 1944, tested 85 strains of coagulase-positive Staph. . . .