BULLOUS KERATOPATHY (FUCHS‘ ENDOTHELIAL DYSTROPHY) TREATED SYSTEMICALLY WITH 4-TRANS-AMINO-CYCLOHEXANO-CARBOXYLIC ACID

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Abstract
Patients (20) with bullous keratopathy (Fuchs'' endothelial dystrophy) were treated systemically with the antifibrinolytic drug tranexamic acid. The effect was evaluated by slit-lamp biomicroscopy, measurement of central corneal thickness and determination of visual acuity. The patients subjective complaints were also registered. The duration of the treatment varied from 3-16 mo. In most cases the treatment was given over several periods with intervening free intervals. In all cases the central corneal thickness decreased and slit-lamp biomicroscopy revealed an improvement. The visual acuity improved and all patients became free of pain. A possible mechanism involving the complement system was discussed and preliminary studies on the composition of the aqueous humour in cases of bullous keratopathy were mentioned.

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