Antifungal Resistance of Candida glabrata Vaginal Isolates and Development of a Quantitative Reverse Transcription-PCR-Based Azole Susceptibility Assay
- 1 September 2008
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (9) , 3424-3426
- https://doi.org/10.1128/aac.00462-08
Abstract
A multiplex quantitative reverse transcription-PCR assay was developed to detect azole resistance in Candida glabrata, an important opportunistic pathogen that develops resistance rapidly. Resistance was defined as a >or=3-fold increase in CDR1 expression by this assay, which proved to be 100% sensitive and 95% specific in comparison to the gold standard broth microdilution assay.Keywords
This publication has 22 references indexed in Scilit:
- Development of a new real-time TaqMan PCR assay for quantitative analyses of Candida albicans resistance genes expressionJournal of Microbiological Methods, 2007
- Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome‐wide expression studiesMolecular Microbiology, 2006
- Candida colonization of the vagina in elderly residents of a long-term-care hospitalEuropean Journal of Clinical Microbiology & Infectious Diseases, 2006
- Pattern of Candida species isolated from patients with diabetes mellitus and vulvovaginal candidiasis and their response to single dose oral fluconazole therapyJournal of Infection, 2006
- Establishing Surrogate Markers for Fluconazole Resistance inCandida albicansMicrobial Drug Resistance, 2005
- Antifungal Susceptibilities of Candida Species Causing Vulvovaginitis and Epidemiology of Recurrent CasesJournal of Clinical Microbiology, 2005
- Mechanisms of Azole Resistance in Clinical Isolates of Candida glabrata Collected during a Hospital Survey of Antifungal ResistanceAntimicrobial Agents and Chemotherapy, 2005
- Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortalityScandinavian Journal of Infectious Diseases, 2004
- Azole Resistance in Candida glabrata : Coordinate Upregulation of Multidrug Transporters and Evidence for a Pdr1-Like Transcription FactorAntimicrobial Agents and Chemotherapy, 2004
- Multiple Patterns of Resistance to Fluconazole in Candida glabrata Isolates from a Patient with Oropharyngeal Candidiasis Receiving Head and Neck RadiationJournal of Clinical Microbiology, 2003