Circadian Rhythm of Irinotecan Tolerability in Mice
- 1 January 2004
- journal article
- Published by Taylor & Francis in Chronobiology International
- Vol. 21 (4-5) , 613-630
- https://doi.org/10.1081/cbi-120040183
Abstract
The toxicity of irinotecan (CPT-11), a topoisomerase-I inhibitor largely used in cancer patients, was investigated as a function of the circadian time of its administration in mice, with mortality,...Keywords
This publication has 32 references indexed in Scilit:
- Circadian chronotherapy for human cancersThe Lancet Oncology, 2001
- Interacting Molecular Loops in the Mammalian Circadian ClockScience, 2000
- Circadian Variation in the Expression of Cell-Cycle Proteins in Human Oral EpitheliumThe American Journal of Pathology, 1999
- Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancerThe Lancet, 1998
- Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancerPublished by Elsevier ,1997
- Pharmacologic Modulation of Reduced Glutathione Circadian Rhythms with Buthionine Sulfoximine: Relationship with Cisplatin Toxicity in MiceToxicology and Applied Pharmacology, 1997
- Chemotherapeutic Agent CPT-11 Induces the New Expression of the Apoptosis Initiator to the CytoplasmExperimental Cell Research, 1996
- Irinotecan (CPT-11) and Characteristic Mucosal Changes in the Mouse Ileum and CecumJNCI Journal of the National Cancer Institute, 1995
- Chronomodulated Versus Fixed-Infusion—Rate Delivery of Ambulatory Chemotherapy With Oxaliplatin, Fluorouracil, and Folinic Acid (Leucovorin) in Patients With Colorectal Cancer Metastases: a Randomized Multi-institutional TrialJNCI Journal of the National Cancer Institute, 1994
- Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11Japanese Journal of Cancer Research, 1993