Isolation of an attenuated myxoma virus field strain that can confer protection against myxomatosis on contacts of vaccinates
- 1 April 2000
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 145 (4) , 759-771
- https://doi.org/10.1007/s007050050669
Abstract
Summary. Twenty MV strains obtained from a survey of field strains currently circulating throughout Spain were analyzed for their virulence and horizontal spreading among rabbits by contact transmission. A virus strain with suitable characteristics to be used as a potential vaccine against myxomatosis in wild rabbit populations was selected. Following inoculation, the selected MV strain elicited high levels of MV specificantibodies and induced protection of rabbits against a virulent MV challenge. Furthermore, the attenuated MV was transmitted to 9 out of 16 uninoculated rabbits by contact, inducing protection against myxomatosis.Keywords
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