Effects of the 5HT1A agonist 8-OH-DPAT, on operant food intake in non-deprived rats
- 1 January 1992
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 3 (1) , 62-64
- https://doi.org/10.1097/00001756-199201000-00016
Abstract
The aim of the present study was to determine whether the hyperphagia produced by systemic administration of 8-OH-DPAT is independent of drug-induced chewing or gnawing behaviour. The effects of 8-OH-DPAT (15.625–500$mUkg-1 s.c.) were therefore investigated on operant food intake in non-deprived rats. Low doses (i.e. 15.625–62.5$mU kg-1) increased operant food intake. Drug-induced stereotypy disrupted operant responding at the higher doses. The results thus suggest that 8-OH-DPAT-induced hyperphagia is independent of chewing or gnawing behaviour.Keywords
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