THE EFFECT OF DESICCATED HOG BILE AND HOG BILE ACID PREPARATIONS ON THE VOLUME AND CONSTITUENTS OF BILE

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Abstract
The effects of 3 gm. daily doses of desiccated hog bile and various preparations of hyodeoxycholic acid, the essential bile acid in hog bile, on the vol. and certain constituents of bile were studied in biliary fistula dogs. Two desiccated hog bile preps., oxidized desiccated hog bile, natural hyodeoxycholic acid, oxidized unconjugated and oxidized conjugated hyodeoxycholic acid were tested. These preps. caused, on the avg., a 35% increase in vol. output, which agrees with the results (38% increase) obtained with "natu- ral" ox-bile salts and oxidized conjugated ox-bile salts. Oxidation of hyodeoxycholic acid does not modify its choleretic property as does oxidation of cholic acid. None of the hog bile preps. significantly altered the synthesis of cholic acid, although the output of cholic acid was rendered more variable. Only about 8% of the carbonyl groups administered in the hog bile preps. was recovered in the bile. When oxidized ox-bile salts were administered from 16-24% was recovered. The hog bile preps. tended to increase total cholesterol output slightly, but had no significant effect on the total output of pigment and the conc. of non-volatile solids. Thus, hog bile and hog bile acid preps. in equivalent amts. do not tend to "thicken" the bile as do the ox-bile salts and the oxidized conjugated ox-bile salts, nor do they "thin" the bile as do the oxidized unconjugated ox-bile salts.

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