Adhesions and incisional hernias following laparoscopic versus open surgery for colorectal cancer in the CLASICC trial

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Abstract
Background: This study investigated adhesive intestinal obstruction (AIO) and incisional hernia (IH) in patients undergoing laparoscopically assisted and open surgery for colorectal cancer. Methods: In a case-note review of patients randomized to the Medical Research Council's Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, primary and key secondary endpoints were AIO and IH admission rates respectively. Results: Of 411 patients, 11 were admitted for AIO: four (3·1 per cent) of 131 patients in the open arm of the trial versus seven (2·5 per cent) of 280 in the laparoscopic arm (difference 0·6 (95 per cent confidence interval (c.i.) − 2·9 to 4·0) per cent). Thirty-six patients developed IH: 12 (9·2 per cent) after open versus 24 (8·6 per cent) after laparoscopic surgery (difference 0·6 (95 per cent c.i. − 5·3 to 6·5) per cent). Results by actual procedure showed higher AIO and IH rates in the 24·5 per cent of patients who converted from laparoscopic to open surgery (AIO: 2·3, 2·0 and 6 per cent; IH: 8·6, 7·4 and 11 per cent—for open, laparoscopic and converted operations respectively). Conclusion: Although this study has not confirmed that laparoscopic surgery reduces rates of AIO and IH after colorectal cancer surgery, trends suggest that a reduction in conversion to open surgery and elimination of port-site hernias may produce such an effect. Registration number for CLASICC trial: ISRCTN74883561 (http://www.controlled-trials.com).
Funding Information
  • Medical Research Council (67 631)