Adverse reactions to tetanus toxoid

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Abstract
A retrospective review of 740 charts of patients with a history of adverse reaction to tetanus toxoid immunization was undertaken. The most common reactions, by history, were local edema and tenderness (33%), fever (15%) and anaphylactoid response (33%). Three patients who had a vesicular eruption at the immunization site were found to have delayed hypersensitivity to Hg. Thirty percent of the patients had received tetanus toxoid within 1 yr and 55% within 5 yr of evaluation. Reactive responses to immediate skin tests were exceedingly rare (< 1%). None of the challenge patients suffered an adverse reaction.

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