Transcriptional regulation in the immune system: all roads lead to AP-1

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Abstract
The mechanisms regulating the development and function of the immune system are diverse and complicated. The signaling pathways and target genes that become activated upon cell‐surface stimulation are currently being defined, and transcription factor activator protein 1 (AP‐1) is proving to be an important regulator of nuclear gene expression in leukocytes. In vitro and in vivo studies have demonstrated that AP‐1 expression is induced after a diverse range of stimuli and that AP‐1 contributes to the regulation of a large number of genes. In this review we will examine the role of AP‐1 during leukocyte activation and differentiation in the immune system. J. Leukoc. Biol. 63: 139–152; 1998.

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