DISPOSITION OF SULFONAMIDES IN FOOD-PRODUCING ANIMALS - PHARMACOKINETICS OF SULFATHIAZOLE IN SWINE
- 1 January 1978
- journal article
- research article
- Vol. 39 (3) , 481-484
Abstract
Disposition of sulfathiazole in plasma and urine of swine was determined following single i.v. and oral doses. Pharmacokinetics of the drug were described by a 1-compartment open model. The drug was rapidly eliminated, mainly by renal excretin of unchanged sulfathiazole and metabolism to acetylsulfathiazole, with a biological half-life of 1.4 h. Sulfathiazole (in solution) was absorbed rapidly (half-life 0.8 h) and relatively completely (73%) following oral administration.This publication has 1 reference indexed in Scilit:
- Relationship Between the Kinetics of the Acetylation and Excretion of Sulfathiazole or Other Sulfonamides and the Occurrence of CrystalluriaJournal of Pharmaceutical Sciences, 1961