In vivo 14C Isotopic Evaluation of Amino Acid Oxidative Catabolism in the Growing Chick

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Abstract
Analysis of the respiratory 14CO2 of growing chicks injected intraperitoneally with [1–14C] or [U-14C]glycine or valine has shown the presence of a delayed ‘slow 14CO2’ exponential component. The half-lives, about 3 h, are independent of the nature of the amino acid and of the age (1–3 weeks) of the animal. As supported by investigations in cycloheximide-treated chicks of the oxidative catabolism of glycine, valine and acetate, slow 14CO2 is significantly associated with the degradation of short-lived proteins.

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