New approach to metabolism of 5?-deoxy-5-fluorouridine in humans with fluorine-19 NMR

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Abstract
Summary The metabolism of 5′-deoxy-5-fluorouridine (5′dFUrd), an antitumor fluoropyrimidine, has been investigated in human biofluids (blood, plasma, urine) using a new method: fluorine-19 NMR spectrometry. This method allows direct study of the biological sample and simultaneous identification of all the fluorinated metabolites. In the blood of a patient treated with 5′dFUrd during a 6-h continuous perfusion, we observed unmetabolized 5′dFUrd, 5-fluorouracil, 5,6-dihydrofluorouracil, and another metabolite which has not previously been reported α-fluoro-β-alanine. The two major metabolites in urine are unmetabolized 5′dFUrd and α-fluoroβ-alanine.