EFFECTS OF TRIPLE THERAPY ON THE PROGRESSION OF MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS

  • 1 February 1987
    • journal article
    • research article
    • Vol. 27  (2) , 56-64
Abstract
Fifty-two pairs of patients with idiopathic diffuse mesangial proliferative glomerulonephritis entered a controlled 3-year prospective trial of a combination regimen of cyclophosphamide, dipyridamole and warfarin. In the treatment group proteinuria decreased significantly (p < 0.01) and renal function remained stable, but in the control group there was no change in proteinuria and creatinine clearance (Ccr) decreased significantly (p < 0.01). The time patients with renal impairment in the control group and those in the treatment group took to reach end stage renal failure was significantly different (6.1 years versus 8.9 years, p < 0.02). Among the patients with IgA nephritis, those in the treatment group (n = 27) had stable renal function and a significant decrease in proteinuria (p < 0.01) but in the control group (n = 21) there was a significant fall in Ccr (p < 0.01) and rise in serum creatinine (p < 0.02) with no change in proteinuria. Among 23 pairs of patients in the study who were matched for renal function and degree of glomerulosclerosis, those in the treatment group had stable renal function and decrease in proteinuria (p < 0.01) whereas those in the control group had decreased Ccr (p < 0.01) but no change in proteinuria.