SOME BIOCHEMICAL EFFECTS OF SPORIDESMIN

Abstract
Sporidesmin inhibits in vitro the respiration of guinea pig and sheep liver homogenates in the presence of substrates which require nicotinamide coenzymes for their oxidation. Succinate oxidation was far less sensitive. Similar results were found with mitochondria.Slight swelling and release of 260 mμ absorbing compounds from mitochondria incubated in the presence of sporidesmin were observed. These results are discussed in relation to those reported elsewhere.