EARLY DIAGNOSIS OF VENOUS THROMBOSIS USING FIBRINOGEN-I-125

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (1) , 5-10
Abstract
Of 102 patients studied with 125I-fibrinogen, 20 had positive test results. Of these, acute thrombophlebitis was confirmed by radiopaque venography in 12 and by clinical evaluation and subsequent hospital course in 8. None of the 30 radiopaque venograms performed in patients with negative fibrinogen-uptake tests revealed evidence of acute thrombophlebitis. Most significantly, 85% of the positive tests were evident within 24 h after administration of the radiopharmaceutical, thus indicating the clinical value of this procedure. Of 24 patients, 42% suspected of acute thrombophlebitis and 7 patients with documented pulmonary emboli had positive fibrinogen tests. Anticoagulation therapy did not prevent a positive 125I-fibrinogen result. Follow-up studies, conducted 1-6 mo. after injection of 125I-fibrinogen, showed no evidence of hepatitis in any of the recipients.

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