Hurler's Syndrome: Demonstration of an Inherited Disorder of Connective Tissue in Cell Culture
- 27 August 1965
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3687) , 987-989
- https://doi.org/10.1126/science.149.3687.987
Abstract
Skin fibroblasts from three patients with Hurler's syndrome were grown in tissue culture and shown to contain metachromatic granules when stained for mucopolysaccharides with toluidine blue O. Similar inclusions were observed in cultures of fibroblasts from other members of the families, who appeared to be clinically normal but who were, judged from studies of pedigree, heterozygous or hemizygous for the abnormal gene.Keywords
This publication has 14 references indexed in Scilit:
- The Hurler syndromeThe American Journal of Medicine, 1965
- EditorialCirculation, 1965
- Mental retardation associated with acid mucopolysacchariduria (heparitin sulfate type)The Journal of Pediatrics, 1963
- Persistence of Mucopolysaccharide Inclusions in Cultures of Lymphocytes from Patients with GargoylismNature, 1962
- PROPERTIES OF ACATALASIC CELLS GROWING IN VITROThe Journal of Experimental Medicine, 1962
- Glucose-6-Phosphate Dehydrogenase Deficient Mutant in Human Cell CultureNature, 1962
- STUDIES ON CELL LINES DEVELOPED FROM THE TISSUES OF PATIENTS WITH GALACTOSEMIAThe Journal of Experimental Medicine, 1961
- QUANTITATIVE STUDIES ON THE PRODUCTION OF ACID MUCOPOLYSACCHARIDES BY REPLICATE CELL CULTURES OF RAT FIBROBLASTS*Annals of the New York Academy of Sciences, 1960
- MUCOPOLYSACCHARIDES PRODUCED IN TISSUE CULTUREThe Journal of cell biology, 1957
- Gargoylism – A mucopolysaccharidosisScandinavian Journal of Clinical and Laboratory Investigation, 1951