TOLERANCE TO DIGITALIS IN EXPERIMENTAL DIPHTHERIA
- 18 December 1926
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 87 (25) , 2047-2049
- https://doi.org/10.1001/jama.1926.02680250005002
Abstract
McCullough, 1 in 1921, observed that the disorders of cardiac rhythm arising in patients with diphtheria were similar to those produced by large doses of digitalis. He deduced, therefore, that digitalis might simply exaggerate disturbances already caused by the diphtheria toxin. In the following year, Bie and Schwensen2 reported the recovery of one of two patients receiving full doses of digitalis. These patients had a form of heart disease from diphtheria that had been uniformly fatal in ten previous cases reported by one of the authors. Obviously, the view as to the danger of digitalis in diphtheria required some modification. It was considered that the results of animal experiments might serve as a guide. Bush 3 had performed some experiments on dogs and frogs, from which he deduced that "the heart is definitely rendered more susceptible to ouabain by the diphtheria toxin." The tables in his paper do notThis publication has 0 references indexed in Scilit: