Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
Top Cited Papers
- 1 June 2009
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 296 (6) , E1195-E1209
- https://doi.org/10.1152/ajpendo.90958.2008
Abstract
Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have important roles in metabolic homeostasis. The molecular identification of genes encoding enzymes that catalyze steps in TAG biosynthesis from glycerol 3-phosphate has revealed an unexpected number of protein isoforms of the glycerol phosphate acyltransferase (GPAT), acylglycerolphosphate acyltransferase (AGPAT), and lipin (phosphatidate phosphatase) families that appear to catalyze similar biochemical reactions. However, on the basis of available data for a few members in which genetic deficiencies in mouse and/or human have been studied, we postulate that each GPAT, AGPAT, and lipin family member likely has a specialized role that may be uncovered through careful biochemical and physiological analyses.Keywords
This publication has 126 references indexed in Scilit:
- Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized LipodystrophyCell Metabolism, 2009
- AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate AcyltransferaseJournal of Biological Chemistry, 2008
- Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymesProceedings of the National Academy of Sciences, 2008
- The lipin protein family: Dual roles in lipid biosynthesis and gene expressionFEBS Letters, 2007
- Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)Published by Elsevier ,2007
- Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin ResistanceJournal of Biological Chemistry, 2007
- Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient miceExperimental and Molecular Pathology, 2007
- Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesisProceedings of the National Academy of Sciences, 2006
- Roles of phosphatidate phosphatase enzymes in lipid metabolismTrends in Biochemical Sciences, 2006
- Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cellsProceedings of the National Academy of Sciences, 2006