Comparison of acute response to polychlorinated biphenyl in liver of rat and channel catfish: A biochemical and morphological study
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 4 (1) , 107-121
- https://doi.org/10.1080/15287397809529648
Abstract
The acute response of liver of channel catfish and rat to poly chlorinated biphenyl was compared on a structural and functional basis. Both the rat and the fish had elevated microsomal enzyme activities. However, in the rat the response was quantitatively greater in all respects. Morphologically, rats responded with lipid accumulation and marked increases in smooth endoplasmic reticulum. Fish liver showed lipid accumulation and increased profiles of rough endoplasmic reticulum with alterations in arrangement that appeared as vesicles and parallel cisternae. Minimal changes were seen in smooth endoplasmic reticulum, which appeared to be increased as discrete foci.Keywords
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