Regiochemistry in the Pauson−Khand Reaction: Has a Trans Effect Been Overlooked?

Abstract
Alkyne−dicobalt hexacarbonyl complexes have been studied by DFT to examine whether electronic differences in the acetylenic substituents could play a role in determining the regiochemical outcome in the Pauson−Khand reaction. It appears that in some instances the regiochemistry is, in fact, governed exclusively by the electronic nature of the acetylenic substituents through the discriminant loss of a carbon monoxide ligand.

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