Splenic Atrophy in Dermatitis Herpetiformis

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Abstract
Twenty-four patients with dermatitis herpetiformis were investigated for splenic atrophy by splenic scan and clearance of 51Cr-labelled heat-damaged red blood cells. Eight of them had definite splenic atrophy. The average splenic cross-sectional area of the remaining 16 with normal clearance times was substantially smaller than normal, suggesting some degree of splenic atrophy. No relationship of splenic hypofunction to intestinal biopsy findings, folate status, reticulin antibody, or treatment with a gluten-free diet or dapsone was evident.