THE CHEMOTHERAPY OF EXPERIMENTAL TUBERCULOSIS II

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Abstract
Of nearly 100 thiosemicarbazones and related compounds tested for antitu-berculous activity in the mouse only 8, all of these being p-sub-stituted benzaldehyde thiosemicarbazones, showed significant reproducible activity. In order of activity, expressed in terms of inverse molar intake required to effect a minimal response, the substituents rank as follows: ethyl sulfonyl = isopropyl > amino = acetamido = dimethylamino > nitro = sulfamyl = methoxy benzaldehyde, 3-thiosemicarbazone. There is no quantitative relationship between in vivo and in vitro antituberculous activity, even among active compounds within the series of the thiosemicarbazones; however, thus far only compounds active in vitro have been found active in vivo.