A New Linear Solvation Energy Relationship for the Solubility of Liquids in Water
- 1 March 1996
- journal article
- Published by American Geophysical Union (AGU) in Journal of Pharmaceutical Sciences
- Vol. 85 (3) , 348-350
- https://doi.org/10.1021/js950228y
Abstract
From a comparison between the linear solvation energy relationship (LSER) and the extended solubility parameter model, it has been found that the solute-solute interaction energy term is missing in the LSER equation. A new LSER equation with the supplementary interaction energy term has been proposed for the solvation process. It is shown that the new LSER equation yields the correct solute-solvent interaction terms for the solubilities of liquids in water.Keywords
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