PREDICTION OF HUMAN ANALGESIC DOSAGES OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) FROM ANALGESIC ED50 VALUES IN MICE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 273  (2) , 212-220
Abstract
The oral analgesic activities (ED50) of 15 NSAID [nonsteroidal anti-inflammatory drug] were determined in the phenylquinone-induced writhing test in mice. ED50 values (mg/kg) were: acetylsalicyclic acid (182), fenclofenac (168), phenylbutazone (129), ibuprofen (82.2), diflunisal (55.6), benoxaprofen (25.4), naproxen (24.1), mefenamic acid (20.7), indomethacin (19.0), meclofenamate Na (9.60), sulindac (7.20), fenoprofen Ca (3.70), tolmetin (1.30), zomepirac Na (0.70) and piroxicam (0.44). Significant linear correlations were found between mouse ED50 values and the various recommended human analgesic or anti-inflammatory dosages. Analgesic ED50 values (mg/kg p.o. [per os]) in mice (X) may be used to predict human dosages (Y) of NSAID according to the equation Y = 8.26X + 535, where Y is the projected human daily dosage (mg).