MYOCARDIAL CHANGES AFTER INFECTION WITH COXSACKIE VIRUS-B3 IN NUDE-MICE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 59  (1) , 13-20
Abstract
Athymic BALB/c-nu/nu(nu/nu) mice were inoculated i.p. with Coxsackie virus B3. The infected nu/nu mice were studied histopathologically, virologically and serologically in comparison with BALB/c-nu/+ (nu/+), BALB/c-+/+(+/+) and conventional ddY/S mice inoculated with the same virus. The virus titer in the hearts of nu/nu mice was roughly similar to that of nu/+ or +/+ and was higher than that of ddY/S. The neutralizing antibody titer in nu/nu mice was slightly lower than that of nu/+ or +/+ mice and somewhat lower than that of ddY/S mice. Histopathologically, there was a lack of mononuclear cells in myocarditis produced by Coxsackie virus B3 in athymic nu/nu mice. Myocarditis with mononuclear cell infiltrations was found in nu/+, +/+ and ddY/S mice. The lack of mononuclear cell reaction was a distinguishing difference in the myocardial changes of athymic nu/nu mice from those in nu/+, +/+ and ddY/S mice. The incidence in the myocardial lesions of nu/nu mice was about the same as those in nu/+, +/+ and ddY/S mice. The intensity of the myocardial changes of nu/nu mice was significantly less than that of the other 3 groups. From the histopathological viewpoint, it is suggested that inflammatory response in the myocardium of mice infected with Coxsackie virus B3 is thymus-dependent.

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