Hypothalamic and Preoptic Area α1-Receptor Concentrations Decrease, and Cerebral Cortical α1-Receptor Concentrations Increase during Postnatal Maturation of Male Guinea Pigs

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Abstract
α1 -Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on α1-receptor concentration in any brain area.