Mediastinal Germ Cell Cancers in Klinefelter's Syndrome

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Abstract
To the editor: Klinefelter's syndrome (XXY) patients have gynecomastia, small testes, azoospermia, and elevated levels of circulating gonadotropins (1). They also have an extra X chromosome that is a result of nondisjunction during meiosis (1). This common genetic disorder occurs in between 1:400 and 1:1000 of male births (1). We report here three patients with Klinefelter's syndrome who presented with a nonseminomatous tumor of the mediastinum. These observations lend support to the suggestion the dysgenetic germ cell tissue in Klinefelter's syndrome patients has an increased malignant potential (2). A 23-year-old patient (Case 1) had had gynecomastia for 5 years. The

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