Protein Adsorption and Cellular Adhesion and Activation on Biomedical Polymers
- 1 June 1990
- journal article
- research article
- Published by SAGE Publications in The International Journal of Artificial Organs
- Vol. 13 (6) , 375-382
- https://doi.org/10.1177/039139889001300609
Abstract
The design and development of new biomedical polymers for clinical application in devices, prostheses, and artificial organs requires a basic and fundamental understanding of biological interactions with biomedical polymers. Efforts in our laboratory have been directed towards appreciating the humoral and cellular interactions which govern protein adsorption and cellular adhesion and activation on biomedical polymers. Information and data are presented on protein adsorption from whole human blood, complement activation and receptors, and monocyte/macrophage adhesion and activation with growth factor release. Supported by experimental evidence, concepts regarding protein/polymer, cell/ polymer, cell/protein/polymer, and cell/cell interactions as they are related to in vivo events are presented.Keywords
This publication has 15 references indexed in Scilit:
- Plasma protein adsorbed biomedical polymers: Activation of human monocytes and induction of interleukin 1Journal of Biomedical Materials Research, 1989
- Role of growth factors in inflammation and repairJournal of Cellular Biochemistry, 1989
- Effect of albumin coating on the in vitro blood compatibility of Dacron® arterial prosthesesBiomaterials, 1989
- Human monocyte/macrophage activation and interleukin 1 generation by biomedical polymersJournal of Biomedical Materials Research, 1988
- In vitro and in vivo interactions of cells with biomaterialsBiomaterials, 1988
- Vascular graft‐associated complement activation and leukocyte adhesion in an artificial circulationJournal of Biomedical Materials Research, 1987
- In vivo leucocyte interactions with the NHLBI-DTB primary reference materials: Polyethylene and silica-free polydimethylsiloxaneBiomaterials, 1987
- The platelet reactivity of vascular graft prostheses: an in vitro model to test the effect of preclottingBiomaterials, 1986
- In vivo biocompatibility studies. V. In vivo leukocyte interactions with biomerJournal of Biomedical Materials Research, 1984
- Initial events in interactions of blood with a foreign surfaceJournal of Biomedical Materials Research, 1969