ANALYSIS OF HUMAN ADRENAL VEIN BLOOD AND ADRENAL GLANDS FOR STEROIDAL SUBSTANCES*

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Abstract
IN 1950, Reich, Nelson and Zaffaroni (1) reported the presence of Kendall's compound F (17-hydroxycorticosterone) in the adrenal vein blood of dogs stimulated with ACTH. Two years later, Zaffaroni and Burton (2) described quantitative estimation of both compounds F and B in the adrenal vein blood of dogs. The concentration of compound F was always greater than that of compound B. A species difference in adrenocortical secretions was observed by Bush (3), who found the ratio of compound F to compound B to be from less than 0.05 in the rat to greater than 20 in the rhesus monkey. Sweat et at. (4) examined the effluent blood from an adrenal gland of a patient with carcinoma of the breast and of a patient with Cushing's syndrome. The effluent adrenal blood from the former contained 290 μg. of compound F and 80 μg. of compound B per 100 ml., whereas the effluent from the latter contained 850 μg. of F and 236 μg. of B per 100 ml. The ratio of F to B in either case was approximately 3.6. More recently, Romanoff, Hudson and Pincus (5) reported the isolation of 4.5 mg. of crystalline compound F and 0.4 mg. of compound B from 500 ml. of effluent adrenal venous blood prior to adrenalectomy, in a patient with metastatic prostatic carcinoma. These values are respectively equivalent to 950 μg. of compound F and 80 μg. of compound B per 100 ml. The ratio of F to B in this case was approximately 11.9.

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