Epidemiologic Study of Inactivated Measles Vaccine

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Abstract
During three successive measles seasons, measles occurred in 11 of 964 vaccinees and 188 of 965 controls, excluding cases which occurred within 14 days of the first injection. Serologic data indicated that a high degree of immunity could be produced and sustained. This immunity did not prevent viral infection and invasion of the vaccinee, as shown by marked rises in antibody titer after natural challenge, but did prevent demonstrable clinical disease. There were no local or systemic reactions. After two years the number of vaccinees in whom full serologic immunity to measles developed without morbidity was the same as the number of controls who actually contracted the disease. Use of inactivated measles-virus vaccine is recommended as a routine office procedure.

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